Alvimopan: a peripheral acting μ-opioid-receptor antagonist used for the treatment of postoperative ileus
نویسندگان
چکیده
Louis Balsama1 & James Weese2† †Author for correspondence 1University of Medicine and Dentistry of New Jersey– School of Osteopathic Medicine (UMDNJ-SOM), Suite 2500 University Doctors Pavilion, 42 E. Laurel Rd, Stratford, NJ 08084, USA 2University of Medicine and Dentistry of New Jersey– School of Osteopathic Medicine (UMDNJ-SOM), Suite 2500 University Doctors Pavilion, 42 E. Laurel Rd, Stratford, NJ 08084, USA Tel.: +1 856 566 2700; Fax: +1 856 566 6438; Email: [email protected]
منابع مشابه
Delayed gastrointestinal recovery after abdominal operation – role of alvimopan
Postoperative Ileus (POI), which occurs after surgical manipulation of the bowel during abdominal operations, is associated with prolonged hospital stay, increasing medical costs, and delayed advancement of enteral diet, which contributes to a significant economic burden on the healthcare system. The use of accelerated care pathways has shown to positively impact gut function, but inevitable po...
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BACKGROUND AND OBJECTIVES Alvimopan, a peripherally acting mu-opioid receptor antagonist, decreased time to gastrointestinal recovery and hospital length of stay in open bowel resection patients in Phase 3 trials. However, the benefit in laparoscopic colectomy patients remains unclear. METHODS A retrospective case series review was performed to study addition of alvimopan to a well-establish...
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Postoperative ileus (POI) is a transient loss of coordinated peristalsis precipitated by surgery and exacerbated by opioid pain medication. Ileus causes a variety of symptoms including bloating, pain, nausea, and vomiting, but particularly delays tolerance of oral diet and liquids. Thus POI is a primary determinant of hospital stay after surgery. 'Fast-track' recovery protocols, opioid sparing ...
متن کاملManagement of postoperative ileus.
Postoperative ileus, a temporary cessation in bowel motility, is a common and significant complication of major surgery. Consequences of postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length of stay, and increased cost to the patient and healthcare system. The traditional, multi-modal approach to the resolution of postoperative ileus incl...
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Postoperative ileus (POI) in patients undergoing abdominal surgery is associated with signifi cant morbidity. In 2008, alvimopan (Entereg®) was approved by the Food and Drug Administration (FDA), and is the only available POI therapy in the United States for patients undergoing bowel resection. Data from preclinical studies demonstrate that alvimopan and its primary metabolite, ADL 08-0011, beh...
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